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備註請放最後面 違者新聞文章刪除

1.媒體來源:

外媒        ScienceAlert

2.記者署名:

Claire Richards & Lana McClements

3.完整新聞標題:

Mini Placentas 3D-Printed in a Lab in Amazing World First

史上第一個人造胎盤組織在實驗室誕生

4.完整新聞內文:

Mini Placentas 3D-Printed in a Lab in Amazing World First
Health
16 September 2025
By Claire Richards & Lana McClements, The Conversation
microscope image of placenta organoid cells

A placental organoid under the microscope. (Claire Richards)

The placenta is a unique organ that exists only during pregnancy, growing at
tumour-like speed to the size of a small dinner plate. The placenta is
essential to the growth of every baby, but we're missing key details about
how it develops.

Studying the placenta during pregnancy is difficult, as taking samples risks
introducing infection or triggering miscarriage. And placental tissue after
birth is very different from its early form.

顯微鏡下的胎盤類器官。 （克萊爾· 理查茲）

胎盤是一個獨特的器官，僅在懷孕期間存在，以腫瘤般的速度生長至小餐盤大小。胎盤對
每個嬰兒的成長至關重要，但我們對其發育過程的關鍵細節卻知之甚少。

研究懷孕期間的胎盤非常困難，因為取樣可能會引發感染或流產。而且出生後的胎盤組織
與其早期形態有很大不同。

Animal placentas are often distinct from human ones, so studying them is of
limited use. Pregnancy researchers have been left in the dark on the critical
early stages of placental development.

In new research published today in Nature Communications, we report the first
3D-printed artificial mini-placentas. These "placental organoids" are an
advance over earlier efforts, and will give scientists new ways to study
pregnancy and shed light on complications like preeclampsia.

動物胎盤通常與人類胎盤截然不同，因此研究它們的用途有限。妊娠研究人員對胎盤發育
的關鍵早期階段一直一無所知。



Tiny organs in the lab

First described in 2009, organoids were a breakthrough in medical research.

Since then, scientists have grown organoids from a wide range of human organs
by taking stem cells and setting them in a gel, like sprinkles suspended in
jelly. This gel mimics the tissue that cells are supported in and allows them
to form clusters as they grow and divide.

A gloved hand holding a clear plastic tray containing puddles of gel with
tiny blobs in them

Organoids suspended in gel, ready to slice and view under the microscope.
(Claire Richards)

實驗室裡的微型器官

類器官於2009 年首次被描述，是醫學研究的突破。



一隻戴著手套的手拿著一個透明的塑膠托盤，托盤裡裝著一灘灘凝膠，裡面有小斑點

懸浮在凝膠中的類器官，準備切片並在顯微鏡下觀察。 （克萊爾· 理查茲）

In 2018, the first placental organoids were grown from trophoblasts – a type
of cell found only in the placenta. Researchers have been using placental
organoids to uncover hidden processes of early pregnancy by copying them in a
dish.

However, most of this research relies on animal-derived gels, which cannot be
modified to reflect the growing environment of the real placenta. Also,
manually suspending cells in gels makes it difficult to create many organoids.



然而，這類研究大多依賴動物性凝膠，而這些凝膠無法進行修改以反映真實胎盤的生長環
境。此外，手動將細胞懸浮在凝膠中也使得建造大量類器官變得困難。

3D printing placentas

Bioprinting is a type of 3D printing technology that uses living cells and
cell-friendly materials to create 3D structures. We mixed trophoblast cells
from the placenta with a synthetic, controllable gel and 3D printed them into
a culture dish in precise droplets, much like an ink-jet office printer.

Our printed cells grew into placental organoids and we compared them to
organoids made with existing manual methods.

3D列印胎盤





Bioprinters allow cells to be positioned precisely in a three-dimensional
structure. (Claire Richards)

The organoids we grew in the bioprinted gel developed differently to those
grown in an animal-derived gel, and formed different numbers of cell
subtypes. This highlighted that the environment organoids are grown in can
control how they mature.

These organoids were very similar to human placental tissue, providing an
accurate model of the early placenta. We could change how the cells organised
themselves by taking young organoids out of the gel and letting them float in
their liquid food.

生物印表機可以將細胞精確地定位在三維結構中。 （克萊爾· 理查茲）

我們在生物列印凝膠中培養的類器官與在動物源凝膠中培養的類器官發育不同，並且形成
了不同數量的細胞亞型。這凸顯了類器官的生長環境可以控制其成熟方式。

這些類器官與人類胎盤組織非常相似，並提供了早期胎盤的精確模型。我們可以將幼稚的
類器官從凝膠中取出，讓它們漂浮在液體食物中，從而改變細胞的組織方式。

Growing placental organoids creates a new way for researchers to study
crucial processes in early pregnancy, unveil the causes of serious conditions
like preeclampsia and find new treatments.

Why understanding the placenta is so important

In 2023, pregnancy complications led to over 260,000 maternal deaths and
millions of infant losses globally.

培養胎盤類器官為研究人員研究早期懷孕的關鍵過程、揭示子癇前症等嚴重疾病的原因以
及尋找新的治療方法開闢了新途徑。

為什麼了解胎盤如此重要

2023年，妊娠併發症導致全球超過26萬名產婦死亡和數百萬名嬰兒死亡。

One serious complication in pregnancy linked to placental dysfunction is
preeclampsia, which affects 5–8% of pregnancies. It causes high blood
pressure and can damage organs, often with little warning.

Preeclampsia can lead to early delivery and serious health risks for both
mother and baby. It also increases the mother's risk of long-term health
problems like heart disease, diabetes, and kidney disease.

與胎盤功能障礙相關的一種嚴重妊娠併發症是子癇前症，佔妊娠總數的5%至8%。它會導致
高血壓，並可能損害器官，而且通常沒有任何預兆。

子癇前症會導致早產，並對母親和嬰兒的健康造成嚴重風險。它還會增加母親患心臟病、
糖尿病和腎臟病等長期健康問題的風險 。

Right now, there's no cure besides delivery because we still don't fully
understand what causes it.

Risk factors such as race, age, obesity, existing high blood pressure,
diabetes, autoimmune disorders and use of assisted reproductive therapy can
identify women who are more likely to develop preeclampsia. Women can
sometimes prevent this by taking low doses of aspirin from early in
pregnancy, but researchers haven't yet found an effective way to prevent all
cases.

If preeclampsia develops, a few drug options are available to treat blood
pressure changes but the only cure is delivery of the baby. This often leads
to premature birth and the challenges that come with being born early.

目前，除了分娩之外沒有其他治療方法，因為我們仍然不完全了解其病因。



如果出現子癇前症，可以使用一些藥物來治療血壓變化，但唯一的解決方法是分娩。這通
常會導致早產以及早產帶來的各種問題。

How better mini-placentas can help

With placental organoids, we can start piecing together the puzzle of
pregnancy complications and test new drugs safely. For example, we exposed
our bioprinted organoids to an immune signal found at high levels in women
with preeclampsia, then tested potential treatments to see how the organoids
grew and responded.

Building on this, bioprinted organoids could be expanded to better understand
pregnancy by using tools like CRISPR to edit genes in cells and uncover
important players in this tightly choreographed process. They could be used
to study infections and test drugs for their safety and effectiveness at
scale.

更好的迷你胎盤如何提供幫助





Bioprinting improves accuracy, repeatability and reduces the need for animals
in research – both for sourcing materials and for drug testing. While some
animal research is still used for testing in a whole living body, this is an
important step towards animal-free research.

As we refine these models, we move closer to a future where pregnancy
complications can be predicted, prevented and treated before they put lives
at risk.The Conversation

Claire Richards, Lecturer in Biotechnology, University of Technology Sydney
and Lana McClements, Associate Professor & Heart Foundation Future Leader
Fellow, University of Technology Sydney

This article is republished from The Conversation under a Creative Commons
license. Read the original article.



隨著我們完善這些模型，我們將更接近一個可以預測、預防和治療妊娠併發症，避免其危
及生命的未來。對話

雪梨科技大學生物技術講師克萊爾‧理查茲(Claire Richards )和雪梨科技大學副教授兼
心臟基金會未來領袖研究員拉娜‧麥克萊門茨 (Lana McClements )

本文轉載自《對話》（The Conversation），並遵循知識共享授權協議。閱讀原文。

https://reurl.cc/3MWW6O

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https://youtu.be/6RLeVaQ9XHk

https://youtu.be/4sH4sWF0LZs

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