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原來上帝真的有設定一鍵刪除功能ㄝ？



https://is.gd/EO6B9y












研究者對650位志願者進行了基因測序，結合40份器官組織細胞RNA樣本進行分析。

結果顯示其中6人攜帶HHV-6基因，兩人攜帶HHV-6A，四人攜帶HHV-6B。RNA測序分析顯示
，這些人體內兩種病毒基因U90和U100是活躍的。



格雷寧格說，尚不明確這些蛋白質可能對人體細胞產生哪些影響，然而鑒於U90的主要作
用是啟用病毒基因組，「它幾乎就是這些遠古病毒嘗試在啟用自己的表現」。


※註:有電視或媒體有報導者，請勿使用爆卦!



原文轉載：

Genes From ‘Fossil’ Virus In Human DNA Found To Be Active
November 11, 2019
Genes from a virus that was stitched into the human genome thousands of years
ago are active, producing proteins in the human brain and other tissues,
according to researchers at the University of Washington School of Medicine
and the Laval University School of Medicine in Quebec, Canada.

Their finding might help explain why people who inherit this “fossil virus”
 appear to have a higher risk of developing neurodegenerative diseases such
as multiple sclerosis and Alzheimer’s.

“There have been some reports that the virus, called human herpesvirus-6,
can reactivate, but if it does, it’s rare,” said Dr. Alex Greninger, UW
assistant professor of laboratory medicine. “What we wanted to know whether
some of the virus’ individual genes were being turned on without full
reactivation of the virus.”

Genes from ‘fossil’ virus in human DNA found to be active
Alex Greninger of the UW School of Medicine, left, and Louis Flamand of Laval
University in Quebec were research project co-leads.
The Journal of Virology published the article recently. Its lead authors were
Vikas Peddu, a bioinformatician in the Greninger lab, and Isabelle Dubuc of
Laval University. The project was led by Greninger and Louis Flamand,
professor in the microbiology and immunology at Laval.

The researchers were interested in two versions of human herpesvirus-6
(HHV-6) that can integrate into chromosomes and be inherited like any other
human gene. HHV-6B causes the common childhood illness, roseola. This
infection affects about 90 percent of children early in life, causing high
fevers and rash. However, relatively little is known about the second virus,
HHV-6A. After infection, both viruses can remain dormant in the body and
reactivate later, particularly in people whose immune systems are suppressed.

In the new study, the researchers looked at a form of the virus that is not
acquired by infection but which about one in a hundred people inherit as part
of their genome. About 8 percent of human DNA comes from viruses inserted
into our genomes in the distant past, in many cases into the genomes of our
pre-human ancestors millions of years ago.

Most of these viral genes come from retroviruses, RNA viruses that insert DNA
copies of their own genes into our genomes when they infect cells. HHV-6 is
unique because it is the only known human DNA herpesvirus that integrates
into the human genome and can be routinely inherited. HHV-6’s genome may
have been accidentally copied into the human genome because it has repeating
DNA sequences that resemble those found in human chromosomes.

In conducting the study, the investigators analyzed a database of genome
sequences of 650 people who gave consent before they died for their DNA
genomes to be researched. The scientists also had access to cellular RNA in
up to 40 tissue samples.

Since cells must convert the instructions of active genes into RNA before
they can be used to make proteins, different RNA sequences in different
tissues reveal which genes are active and inactive in different cell types.



“A lot of human genomicists have overlooked these integrated HHV-6 sequences
in human genomes. They’re not in the human reference sequences and they’re
not common enough to rise on the radar,” Greninger said.

The researchers identified six individuals who had HHV-6 integrated in their
genomes: two with HHV-6A and four with HHV-6B. The RNA sequences revealed
that in these individuals, a number of viral genes were being actively
expressed, in particular one gene called U90 and another called U100.

In most tissues, the level of expression was low and sporadic, but the
highest expressions were found in the esophagus, testes, adrenal gland and
brain. The gene U100 codes for a viral protein that is part of the viral
outer shell, or envelope. U90 codes for a protein known as a transactivator,
which means it promotes the expression of other genes.

Working with samples they had collected as part of another study, the
Canadian researchers showed that individuals with the inherited HHV-6 genes
mounted a greater immune response to viral proteins.

“This suggests that even though the viral genes had been long been part of
their genome, the immune systems of people who carried the genes still
recognized the viral proteins as foreign,” said Flamand. “We still need to
know more how the immune system gets educated by or against these endogenous
viruses to understand what this increased immune response against HHV-6
proteins means.”

What biological effect these proteins may be having on human cells is
unknown, Greninger said. “The transactivator protein U90 is primarily
responsible for turning on the viral genome. It almost as though this
fossilized virus is trying to reactivate itself.”

“One question we want answer is, ‘What effect does having this 150 kb viral
genome present enact on expression of your human genes? We don’t know
because it is present only in about 1% of the population. It will require
analysis of data from very large biobanks that have associated RNA
transcription sequences and the full medical records of the participants to
identify which diseases these inherited HHV-6 genomes may play a role in,”
 he said.

This work was made possible with grants from the Heart and Stroke Foundation
of Canada and Canadian Institutes of Health Research.


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遠離瀋陽，往產柚子的省份逃！ https://imgur.com/vgUPA7A 紅花開盡白花開(香港)
，紫金山上美人來(流星雨)。十九佳人五五歲(四十九年竊國/日應十一)
有福之人住山莊。能逢木兔方為壽。中國柚子主要產地是在福建、廣東、廣西、四川、
湖南、浙江這幾個省份。 https://imgur.com/HzkEbnV 淺水鯉魚(瀋陽)終有難，
百載繁華一夢消。20年前，鞍山市開始發展養魚業，如今觀賞魚養殖已向遼陽、瀋陽、
營口、丹東等地延伸。據不完全統計，目前單單鞍山地區擁有觀賞魚養殖戶1000餘家。

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(GETpoint.): [爆卦] 人體可自行啟用遠古病原體基因致病 - Gossiping板