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備註請放最後面 違者新聞文章刪除

1.媒體來源:

外媒    sciencealert

2.記者署名:

Michelle Starr

3.完整新聞標題:

Scientists Engineered a Plant to Produce 5 Different Psychedelics at Once

五重迷幻終極植物誕生!

4.完整新聞內文:

Scientists Engineered a Plant to Produce 5 Different Psychedelics at Once
Health
02 April 2026
By Michelle Starr
Scientists Engineered a Plant to Produce 5 Different Psychedelics at Once
(Victor de Schwanberg/Science Photo Library/iStock/Getty Images)

What do plants, toads, and mushrooms have in common? They can all produce
psychedelic substances – and now their powers have been combined in one
plant, like a trippier Captain Planet.

科學家改造了一種植物，使其同時產生5種不同的迷幻劑。
2026年4月2日
經過米歇爾· 斯塔爾
科學家改造了一種植物，使其同時產生5種不同的迷幻劑。
（圖片來源：Victor de Schwanberg／Science Photo Library/iStock／Getty Images）

植物、蟾蜍和蘑菇有什麼共同點？它們都能產生致幻物質——現在，它們的力量被結合在
了一種植物中，就像一個迷幻版的地球超人。

In a wild first, scientists have taken the genes these organisms use to make
five natural psychedelics and introduced them into a tobacco plant (Nicotiana
benthamiana), which then produced all five compounds simultaneously.

As interest grows in psychedelics as potential treatments for illnesses such
as depression, anxiety, and PTSD, the newly developed system could offer
scientists a new way to produce these compounds for research purposes.

"[Our] strategy established a heterologous plant system for the production of
five prominent therapeutically valuable compounds, their derivatives, and
nonnatural plant analogs, providing a starting point for their production in
plants," writes a team led by researchers at the Weizmann Institute of
Science in Israel.

科學家史無前例地提取了這些生物體用來製造五種天然迷幻劑的基因，並將它們導入菸草
植物（本氏菸草）中，結果該植物同時產生了所有五種化合物。





https://www.sciencealert.com/images/2026/04/dmt-plants.jpg

Tryptamine psychedelics are a class of compounds that includes psilocin,
psilocybin, and a number of dimethyltryptamine (DMT) compounds. The ability
to produce these substances has emerged in diverse organisms across the tree
of life – plants, fungi, and animals.

In recent years, a number of studies have shown that tryptamine psychedelics
may represent an untapped resource when it comes to mental health treatments.

However, progress in this field remains limited, in part due to regulatory
restrictions, underscoring the need for more research. This creates practical
challenges for scientists.

色胺類迷幻藥是一類化合物，包括裸蓋菇素、 賽洛西賓和多種二甲基色胺（DMT）化合物

近年來，許多研究表明，色胺類迷幻劑在精神健康治療方面可能代表著一種尚未開發的資
源。

然而，由於監管限制等原因，該領域的進展仍然有限，這凸顯了進行更多研究的必要性。
這也給科學家帶來了實際挑戰。

"Traditionally, the supply of psychedelics relies on natural producers,
mainly plants, fungi, and the Sonoran Desert toad," the researchers write.

"Harvesting these organisms for their psychoactive compounds raises
ecological and ethical concerns, being increasingly threatened by habitat
loss and overexploitation."

In an effort to tackle this, plant scientists Paula Berman and Janka Höfer
and their team set out to map and rebuild the biochemical pathways behind
these compounds.

They identified the key genes used by two plants – Psychotria viridis and
Acacia acuminata – to make DMT, and the step-by-step chemical pathways
involved in producing the compound.

研究人員寫道：“傳統上，迷幻劑的供應依賴於天然生產者，主要是植物、真菌和索諾蘭
沙漠蟾蜍。”

“採集這些生物體以獲取其精神活性化合物會引發生態和倫理方面的擔憂，而且它們正日
益受到棲息地喪失和過度開發的威脅。”

為了解決這個問題，植物科學家 Paula Berman 和 Janka Höfer 及其團隊著手繪製和重
建這些化合物背後的生化途徑。

他們確定了兩種植物——綠葉茜草和尖葉金合歡——用於製造DMT的關鍵基因，以及生產
該化合物所涉及的逐步化學途徑。

Then, they combined these with genes and pathways already known from
psychedelic mushrooms (Psilocybe cubensis) and the cane toad (Rhinella
marina), added supporting enzymes from rice and cress, then genetically
introduced the combined genetic toolkit and kaboodle into tobacco plants
(Nicotiana benthamiana).

The tobacco was chosen not because of its own drug production, but because
it's basically the lab rat of plant species, with its fast growth.

Finally, the team carefully monitored the plant's production of five
psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin
from mushrooms; and bufotenin and 5-MeO-DMT from toads.





The modified tobacco plants were found to produce all five compounds
simultaneously. Because the different production pathways compete for the
same resources, some compounds were produced in lower quantities than in
their original sources.

However, the production was high enough to suggest that with a bit more
tweaking, the system could function as a biological tryptamine factory for
researchers.

Berman, Höfer, and their team also took it a step further. By tweaking the
enzymes involved in the tryptamine production pathway, the researchers were
able to produce modified versions of the compounds that do not naturally
occur in plants, and which may also have therapeutic value.

研究發現，基因改造菸草植株能夠同時產生全部五種化合物。由於不同的合成途徑會競爭
相同的資源，因此某些化合物的產量低於其原始來源。

然而，產量之高表明，稍加調整，該系統就能作為研究人員的生物色胺工廠。

伯曼、霍弗及其團隊更進一步。透過調整色胺生成途徑中的酶，研究人員成功生產出植物
中天然不存在的、可能具有治療價值的化合物的改良版本。

With further research, the system could be optimized to research
requirements, or even help design new compounds tailored for specific
therapeutic applications.

"Blending catalytic functions across the tree of life, coupled with metabolic
engineering guided by rational protein design of mutant enzymes, enabled
substantially more efficient in planta production of the indolethylamine
components," the researchers write.

"This work establishes a versatile platform for concurrent biosynthesis and
diversification of psychoactive indolethylamines, paving the way for their
production in plants."

The research has been published in Science Advances.

透過進一步研究，該系統可以針對研究需求進行最佳化，甚至可以幫助設計針對特定治療
應用的新化合物。

研究人員寫道：“將生命之樹上的催化功能融合起來，再加上以突變酶的合理蛋白質設計
為指導的代謝工程，使得吲哚乙胺成分在植物體內的生產效率大大提高。”

“這項工作建立了一個多功能平台，可同時進行精神活性吲哚乙胺的生物合成和多樣化，
為在植物中生產這些化合物鋪平了道路。”

這項研究成果已發表在《科學進展》期刊。

5.完整新聞連結 (或短網址)不可用YAHOO、LINE、MSN等轉載媒體:

https://reurl.cc/r0LO4E

6.備註:

太頂了，基因工程的正確用法。

https://youtu.be/DJfg39WkMvE

https://i.urusai.cc/HHqHS.jpg

https://youtu.be/j_RgTzV6yAY?si=dr1TXbgIukfeMv_I&t=120

ヽ(∀ﾟ )人(ﾟ∀ﾟ)人( ﾟ∀)人(∀ﾟ )人(ﾟ∀ﾟ)人( ﾟ∀)ﾉ


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※ 作者: STAV72 2026-04-02 19:42:40
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